Mitochondrial DNA
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Mitochondrial DNA

Mitochondrial DNA

Mitochondrial DNA is inherited merely through the maternal line, as sperm contribute no mitochondria to the fertilized oocyte.

Mitochondrial donation is a specialized form of in-vitro fertilization in which the future baby’s mitochondrial DNA comes from a third party.  There are basically two possible techniques which are cytoplasmic transfer and spindle chromosomal complex transfer. These treatments may result in human offspring with three genetic parents, the so-called three-parent babies. The procedure is intended to prevent mitochondrial diseases pass on to the offspring.

Cytoplasmic transfer is an assisted reproductive technology fertility technique whereby cytoplasm from a donor egg is injected into an egg with compromised mitochondria

A spindle chromosomal complex transfer is a genetic manipulation technique where the donor’s nuclear DNA but not her mitochondrial DNA is transferred to the receiving oocyte.

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