Mitochondrial DNA is inherited merely through the maternal line, as sperm contribute no mitochondria to the fertilized oocyte.
Mitochondrial donation is a specialized form of in-vitro fertilization in which the future baby’s mitochondrial DNA comes from a third party. There are basically two possible techniques which are cytoplasmic transfer and spindle chromosomal complex transfer. These treatments may result in human offspring with three genetic parents, the so-called three-parent babies. The procedure is intended to prevent mitochondrial diseases pass on to the offspring.
Cytoplasmic transfer is an assisted reproductive technology fertility technique whereby cytoplasm from a donor egg is injected into an egg with compromised mitochondria